RecruitingNot ApplicableNCT06911229

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Sponsor

University of Florida

Enrollment

60 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how the brain controls walking and what causes "freezing of gait" — a sudden inability to take a step — in people with Parkinson's disease who already have a deep brain stimulator (DBS) implanted. **You may be eligible if...** - You have been diagnosed with Parkinson's disease by a specialist - You already have a deep brain stimulator that has been working stably for at least 6 months - You are between 18 and 80 years old - You do not have dementia - You can walk without a walking aid or another person's help **You may NOT be eligible if...** - You have had any other neurological surgery besides DBS - Doctors suspect you have a different neurological condition such as atypical parkinsonism or Alzheimer's disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.