RecruitingNot ApplicableNCT06951919

HOBSCOTCH-MS-Efficacy Trial

HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS) - Efficacy Trial


Sponsor

Dartmouth-Hitchcock Medical Center

Enrollment

125 participants

Start Date

Sep 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also assess the ability of the HOBSCOTCH-MS program to improve quality of life in caregivers of patients with multiple sclerosis and to reduce caregiver burden. Enrolling with a Caregiver is optional for MS participants. Investigators will compare two groups of MS participants and their Caregiver (enrolling with a Caregiver is optional): one who receives HOBSCOTCH-MS immediately (Group 1) and another group that will receive HOBSCOTCH-MS (Group 2) after a 3-month waiting period. Participants will be in the study for about 6 months total. HOBSCOTCH-MS involves 45 to 60 minute one on one virtual sessions with a certified Cognitive Coach including a "pre" program session and 8 weekly sessions thereafter. Participants will learn about problem solving therapy and mindfulness or relaxation training. MS participants are asked to do short homework assignments and both MS and Caregiver participants are asked to keep a brief daily diary on a smart phone app. All participants complete study questionnaires or surveys at enrollment, 3 months later and at 6 months (at the end of the study). After completing the intervention, MS Participants and their Caregivers may also participate in an optional one-time Key Informant Interview for qualitative analysis in an effort to further adapt and improve the HOBSCOTCH-MS in the future.


Eligibility

Min Age: 20 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing HOBSCOTCH, a home-based online cognitive skills training program for people with multiple sclerosis (MS) who are experiencing memory and thinking difficulties. The program teaches practical strategies to cope with cognitive challenges, and the study is examining whether it improves cognitive function and quality of life. **You may be eligible if...** - You are between 20 and 75 years old - You have been diagnosed with relapsing or progressive MS - You have at least a 12th grade or GED level of education - You speak fluent English and have access to the internet and a phone - You are experiencing subjective memory or thinking difficulties **You may NOT be eligible if...** - You have a current psychiatric disorder such as schizophrenia, bipolar disorder, or substance use disorder - You have another neurological condition (epilepsy, brain tumor, severe brain injury) that could explain your cognitive difficulties - You have a diagnosed developmental, sensory, or motor disorder that would interfere with study tasks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALHome Based Self- management and Cognitive Training Changes lives in Multiple Sclerosis (HOBSCOTCH-MS)

HOBSCOTCH is a home-based self-management program to treat cognitive symptoms and improve quality of life, while minimizing the barriers of access to care. The program is based on Problem Solving Therapy (PST) and teaches problem solving strategies and compensatory mechanisms to help manage cognitive dysfunction and enhance quality of life. HOBSCOTCH-MS is an adaptation of the HOBSCOTCH program specifically for people who have multiple sclerosis. It incorporates education about these conditions and cognition into the education module.


Locations(1)

Dartmouth-Health Lebanon

Lebanon, New Hampshire, United States

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NCT06951919


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