TMS for Cognitive Decline in Aging and Preclinical AD

This study tests whether transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique using magnetic pulses applied to the scalp — can improve memory and thinking in older adults who are cognitively normal or in the very early stages of Alzheimer's disease (before symptoms appear). Researchers want to understand if TMS can slow cognitive decline. **You may be eligible if...** - You are between 40 and 99 years old - You are a native English speaker - You are cognitively normal or have been identified as having preclinical Alzheimer's disease (changes in the brain but no symptoms yet) - You are willing to undergo brain imaging (MRI) and memory testing at multiple time points **You may NOT be eligible if...** - You have had a serious head injury involving loss of consciousness - You have a major neurological or psychiatric condition - You have a known structural brain abnormality (such as a brain tumor or a past stroke) - You have any implant or metal in your body that is incompatible with MRI (e.g., a pacemaker, aneurysm clip, or cochlear implant) - You have a personal or family history (first-degree relative) of unprovoked seizures - You take medications that significantly lower the seizure threshold - You have a longstanding history (more than 10 years) of serious alcohol or substance abuse Talk to your doctor to see if this trial is right for you.