Probiotic Intervention on Body Weight
An Interventional Study Investigating the Effects of Probiotics on Body Weight and Metabolic Homeostasis
Chinese Academy of Sciences
140 participants
Jun 10, 2025
INTERVENTIONAL
Conditions
Summary
This study is a randomized controlled trial with 120 overweight or obese (body-mass index, BMI, ≥ 24 kg/m²) participants and 20 normal-weight participants. Twelve weeks of energy-restricted nutritional and lifestyle intervention with placebo, Lactobacillus paracasei LC-19 (LC-19), or semaglutide (a glucagon-like peptide-1 receptor agonist, GLP-1RA) will be randomly conducted in the overweight or obese participants. The primary goal is to clarify the roles of LC-19 and semaglutide in weight reduction and in improving energy, glucose, and lipid metabolism, while also comparing side effects, adverse events, and long-term outcomes such as weight regain between these two interventions. In addition, the study will explore key factors affecting intervention response to provide evidence for optimizing individualized intervention strategies.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Participants will receive dietary advice, behavior guidance and nutritional and lifestyle education based on dietary guidelines.
Participants will receive dietary advice, behavioral guidance and nutritional and lifestyle education by dietitian and physicians. App-connected wearable devices will be utilized to monitor their dietary intakes and App-connected scale will be used to monitor their weight changes during interventions.
Participants will receive one bag (2 g; 1 × 10¹² CFU) daily of LC-19.
participants will receive daily one bag of LC-19 (10\^12 cfu/bag).
Participants will receive prescibed semaglutide therapy
Locations(1)
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NCT06989177