Triamcinolone Nanocapsules After Endoscopic Nasal Surgery
Clinical Evaluation of Triamcinolone Acetonide-loaded Nanoparticles For Nasal Postoperative Application
Deraya University
50 participants
May 1, 2026
INTERVENTIONAL
Conditions
Summary
This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery. Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.
Eligibility
Inclusion Criteria8
- Adults aged 18 to 60 years.
- Patients scheduled to undergo one of the following procedures:
- Functional endoscopic sinus surgery
- Endoscopic turbinoplasty
- Endoscopic septoplasty
- Diagnosis of chronic rhinosinusitis and/or nasal polyps requiring surgical intervention.
- Ability and willingness to provide written informed consent.
- Ability and willingness to comply with study treatment and scheduled follow-up visits.
Exclusion Criteria11
- Known hypersensitivity to triamcinolone acetonide.
- Known hypersensitivity to any component of the polymeric nanocapsule formulation.
- Systemic contraindication to corticosteroid therapy.
- Active severe nasal or sinonasal infection at the time of enrollment or treatment.
- Pregnancy or breastfeeding, if excluded in the approved protocol.
- Uncontrolled diabetes mellitus, if corticosteroid exposure is considered clinically relevant.
- Immunosuppression or use of immunosuppressive therapy.
- Recent use of systemic or intranasal corticosteroids within the protocol-defined washout period.
- Participation in another clinical trial.
- Any medical or psychiatric condition that may interfere with informed consent, study treatment, or follow-up.
- Inability to complete the required questionnaires or follow-up visits.
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Interventions
Triamcinolone acetonide incorporated into polymeric nanocapsules prepared using a nanoprecipitation method will be administered topically to the postoperative nasal cavity.
Participants will receive postoperative nasal irrigation with 0.9% sodium chloride solution.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07714525