Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Washington University School of Medicine
20 participants
Jul 28, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.
Eligibility
Inclusion Criteria6
- Participants must be residents of Illinois or Missouri and able to come to St. Louis offices in person.
- Ages 50-70
- Able to come to the research center for testing and intervention visits.
- Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)).
- BMI≥27 or Body Roundness index ≥6
- Able to provide informed consent.
Exclusion Criteria7
- Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records.
- Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation.
- Unable to perform study assessments.
- Alcohol or substance abuse within 6 months per self-report or medical records.
- Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity.
- Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine)
- PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention
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Interventions
Behavioral lifestyle changes including an exercise program, healthy eating recommendations, reviewing medical management for cardiometabolic risk conditions, deprescribing review for brain toxic meds, online cognitive training, as well as recommendations to improve sleep quality, or smoking cessation as needed
dasatinib 100mg The intervention will involve the participant taking dasatinib 100mg and quercetin 1250ng combined, intermittenly throughout the trial
e intervention will involve the participant taking dasatinib 100mg and quercetin 1250ng combined, intermittenly throughout the trial
Participants will be prescribed vortioxetine to take daily, in combination with online cognitive training
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07000734