RecruitingNot ApplicableNCT07019246

Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery

Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery - A Randomized, Double-blind, Controlled Study


Sponsor

Tongji Hospital

Enrollment

166 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol for total intravenous anesthesia in elderly patients undergoing abdominal surgery.


Eligibility

Min Age: 65 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two anesthesia regimens — one using propofol alone and one using a mix of propofol and etomidate — in elderly patients having abdominal surgery, to see which is safer and causes fewer side effects. **You may be eligible if...** - You are scheduled for planned abdominal surgery under general anesthesia expected to last 1–4 hours - Your anesthesia risk level is ASA class I–III - Your BMI is between 18 and 28 **You may NOT be eligible if...** - You had septic shock or multiple organ failure in the last 14 days - You had a stroke or mini-stroke (TIA) in the last 3 months - You had a heart attack or unstable chest pain in the last 3 months - You have uncontrolled diabetes or diabetic complications - You have very high potassium levels in your blood - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEP mixture

Patients will receive etomidate - propofol mixture during induction and maintenance. Sufentanil 0.2-0.7 μg/kg,Cisatracurium 0.15 mg/kg,EP mixture(E:P=1:2) 0.1-0.25 ml/kg for induction, EP mixture 0.4\~ 1.2 ml/kg/h and remifentanil 0.05μg/kg/min \~0.3 μg/kg/min for maintenance.

DRUGPropofol

Patients will receive propofol during induction and maintenance.Sufentanil 0.2-0.7 μg/kg,Cisatracurium 0.15 mg/kg,propofol 0.1-0.25 ml/kg for induction, propofol 0.4\~ 1.2 ml/kg/h and remifentanil 0.05μg/kg/min \~0.3 μg/kg/min for maintenance.


Locations(1)

Tongji hospital

Wuhan, Hubei, China

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NCT07019246


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