Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

This study is testing whether a breathing stimulant drug called doxapram can help the diaphragm (the main breathing muscle) work better in patients with severe chronic lung disease (COPD) who are on a breathing machine and being weaned off it. **You may be eligible if...** - You have moderate to severe COPD - You are currently on a ventilator (breathing machine) - You are in a spontaneous breathing trial — a test to see if you can breathe on your own **You may NOT be eligible if...** - You have refused to participate - You have an allergy to doxapram - You have a neuromuscular disorder (a condition affecting your muscles or nerves) - Doctors are unable to evaluate your diaphragm with ultrasound Talk to your doctor to see if this trial is right for you.