RecruitingNCT07024875

Neuroimaging of Parkinson's

Precision Neuroimaging of Parkinson's Disease

Sponsor

Washington University School of Medicine

Enrollment

120 participants

Start Date

Aug 1, 2025

Study Type

OBSERVATIONAL

Conditions

Parkinsons Disease (PD)

Summary

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is using specialized brain scans (neuroimaging) to better understand changes in the brain in people with Parkinson's disease compared to healthy individuals without the condition. **You may be eligible if...** - You have been clinically diagnosed with Parkinson's disease (and do not yet have dementia) - OR you are a healthy volunteer with no neurological conditions and no first-degree relatives with Parkinson's disease - Your memory and thinking are reasonably intact **You may NOT be eligible if...** - You have any neurological condition other than Parkinson's disease - You have had a significant head injury with loss of consciousness for more than 5 minutes - You have schizophrenia, bipolar disorder, or epilepsy - You have dementia or scored below 24 on a standard memory test - You have metal implants or claustrophobia (which prevent MRI scans) - You weigh over 300 lbs (due to MRI scanner limits) - You are undergoing active cancer treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

East Imaging Building

St Louis, Missouri, United States

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NCT07024875

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