RecruitingPhase 1NCT07064005

Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.

Brain Glutathione (GSH) Enrichment Through Gamma-glutamylcysteine (GGC) Supplementation in Early Parkinson's Disease Patients for Reduction of Extrapyramidal Motor Disturbances and Halting Cognition Decline: A Pilot Trial

Sponsor

Pravat Mandal

Enrollment

12 participants

Start Date

Mar 20, 2026

Study Type

INTERVENTIONAL

Conditions

Parkinsons Disease (PD)

Summary

This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate: 1. To study the enrichment of master antioxidant, glutathione (GSH) levels in brain and blood of these PD patients compared to baseline due to GGC supplementation. 2. To study the changes in motor function, cognitive skills in PD patients due to GGC oral supplementation 3. To study impact of GGC on gut health on the PD patients.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a supplement called gamma-glutamylcysteine (a building block for glutathione, a natural antioxidant) can boost antioxidant levels in the brain and improve brain health in people with Parkinson's disease. **You may be eligible if...** - You are between 50 and 80 years old - You have a confirmed diagnosis of Parkinson's disease - You have normal or near-normal cognitive function (MoCA score of 26 or above) - You are able to read and write in English **You may NOT be eligible if...** - You have a pacemaker, metal implants, aneurysm clips, or other devices incompatible with MRI scanning - You have claustrophobia - You have been diagnosed with Parkinson's disease dementia or dementia with Lewy bodies - You have a history of cancer, active psychosis, or significant kidney or liver disease - You are currently taking antioxidant supplements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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