RecruitingNCT07175922

Research Into the Expression of the csgA-gene and How it Changes in Patients With Parkinson's Disease

Evaluation of csgA Prevalence, Gene Expression and Week-to-Week Variability in Participants With Parkinson's Disease and a History of Gastrointestinal Dysfunction

Sponsor

Vertero Therapeutics

Enrollment

200 participants

Start Date

Sep 25, 2025

Study Type

OBSERVATIONAL

Conditions

Parkinsons Disease (PD)

Summary

This study seeks to understand the prevalence and variability of a gut bacteria gene called csgA in people with Parkinson's Disease. This understanding could inform development of potential new therapies targeting the gut in Parkinson's Disease.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a gene called csgA — which is linked to bacterial activity in the gut — changes in people with Parkinson's disease who also experience digestive problems. The gut-brain connection in Parkinson's is an emerging area of research. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with Parkinson's disease within the last 10 years - You currently have or have had gastrointestinal problems such as constipation - You can read, speak, and understand Dutch well enough to complete all study assessments - You are able to provide written informed consent **You may NOT be eligible if...** - You have a clinically significant gastrointestinal disorder (other than constipation related to Parkinson's) - You are unable or unwilling to provide consent - You cannot understand the study procedures in Dutch Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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