RecruitingNot ApplicableNCT07424365

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

Investigation of Vagus Nerve Stimulation to Augment Executive Functioning


Sponsor

University of Colorado, Denver

Enrollment

80 participants

Start Date

May 19, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities. This process, called transcutaneous auricular vagus nerve stimulation (taVNS), could help improve brain function in both healthy individuals and people with Parkinson's disease (PD).


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether gentle electrical stimulation of the vagus nerve — delivered through the ear — can improve thinking, memory, and mental focus in healthy adults and people with Parkinson's disease. The vagus nerve connects the brain to many parts of the body and plays a role in brain function. **You may be eligible if...** - You are between 18 and 65 years old - You are able to follow written and spoken instructions - If you have Parkinson's disease: you have been clinically diagnosed and do not have severe motor or thinking problems **You may NOT be eligible if...** - You have an uncontrolled or serious medical condition - You have an ear infection or abnormal ear anatomy - You have an electronic implant such as a pacemaker or cochlear implant - You have uncorrected vision problems that would interfere with the tasks - You have other significant diseases that might affect participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEtranscutaneous auricular vagus nerve stimulation

Electrical stimulation targeting the auricular branch of the vagus nerve

DEVICEsham stimulation

Sham stimulation of the outer ear that does not target the vagus nerve


Locations(1)

Clinical Translational Research Center at CU Anschutz

Aurora, Colorado, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07424365


Related Trials