Chronic Low Back Pain (CLBP) Clinical Trials

27 recruitingLast updated: May 29, 2026

There are 27 actively recruiting chronic low back pain (clbp) clinical trials across 16 countries. Studies span Not Applicable, Phase 3, Phase 2. Top locations include Hong Kong, Hong Kong, Auburn, Alabama, United States, Austin, Texas, United States. Updated daily from ClinicalTrials.gov.


Chronic Low Back Pain (CLBP) Trials at a Glance

27 actively recruiting trials for chronic low back pain (clbp) are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 21 trials, with the heaviest enrollment activity in Hong Kong, Auburn, and Austin. Lead sponsors running chronic low back pain (clbp) studies include The Hong Kong Polytechnic University, Bart Koes, and Cairo University.

Browse chronic low back pain (clbp) trials by phase

Treatments under study

About Chronic Low Back Pain (CLBP) Clinical Trials

Looking for clinical trials for Chronic Low Back Pain (CLBP)? There are currently 29 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Low Back Pain (CLBP) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Low Back Pain (CLBP) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting
Not Applicable

Chronic Low Back Pain and Osteopathic Manipulation Treatment

Chronic Low Back Pain (CLBP)Low Back Pain
Edward Hines Jr. VA Hospital48 enrolled1 locationNCT07161661
Recruiting
Phase 3

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Chronic Low Back Pain (CLBP)ObesityOverweight
Eli Lilly and Company586 enrolled40 locationsNCT07035093
Recruiting
Not Applicable

How Osteopathic Treatment Affects the Leg and Foot in People With Low Back Pain

Chronic Low Back Pain (CLBP)
Edward Via Virginia College of Osteopathic Medicine20 enrolled1 locationNCT07193212
Recruiting
Not Applicable

Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

Chronic Low Back Pain (CLBP)FibromyalgiaLupus Erythematosus, Systemic+1 more
University of Michigan125 enrolled1 locationNCT06208514
Recruiting
Not Applicable

Neuroimmune Responses to Exercise in Chronic Back Pain

Chronic Low Back Pain (CLBP)
McGill University216 enrolled1 locationNCT07497425
Recruiting
Not Applicable

Biopsychosocial Model-based Care Versus Routine Physical Therapy in Chronic Back Pain

Chronic Low Back Pain (CLBP)
Lahore University of Biological and Applied Sciences80 enrolled1 locationNCT07280806
Recruiting
Not Applicable

Clinical Research on the Comparative Effectiveness and Safety of JHG002 Therapy for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial

Chronic Low Back Pain (CLBP)
Jaseng Medical Foundation96 enrolled4 locationsNCT07304076
Recruiting
Not Applicable

A Mediation Analysis Investigating Dry Needling Treatment Mechanisms in a Chronic Low Back Pain Population

Chronic Low Back Pain (CLBP)
University of Florida71 enrolled1 locationNCT06940492
Recruiting
Not Applicable

A Superiority Trial of Radiofrequency Ablation for Low Back Pain

Chronic Low Back Pain (CLBP)
University of Washington300 enrolled3 locationsNCT07222462
Recruiting
Not Applicable

Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain

Chronic Low Back Pain (CLBP)
Laval University96 enrolled2 locationsNCT06999772
Recruiting
Not Applicable

Effects of PEMM in Chronic Low Back Pain Women With Urinary Incontinence

Chronic Low Back Pain (CLBP)Pelvic PainUrinary Incontinence (UI)+2 more
Hamad Medical Corporation200 enrolled1 locationNCT07351851
Recruiting
Not Applicable

Treatment Validation for Myofascial Pain

Chronic Low Back Pain (CLBP)myofacial pain
Ajay Wasan, MD, Msc80 enrolled1 locationNCT07133139
Recruiting
Phase 2

Resilience Enhancement Following Sleep Treatment

Chronic Low Back Pain (CLBP)Insomnia
University of Virginia300 enrolled1 locationNCT07298941
Recruiting

Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study

Chronic Low Back Pain (CLBP)Chronic InsomniaNeuroinflammation
Vrije Universiteit Brussel80 enrolled1 locationNCT06973837
Recruiting
Not Applicable

Comparison of the Immediate Effect of Passive vs. Passive-Active Hamstring Stretching on Flexibility in Patients With Chronic Low Back Pain

Chronic Low Back Pain (CLBP)
University Hospital, Clermont-Ferrand90 enrolled2 locationsNCT06888895
Recruiting
Not Applicable

A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain

Chronic Low Back Pain (CLBP)
Saint Francis Hospital30 enrolled1 locationNCT07215104
Recruiting
Not Applicable

Acceptance and Commitment Therapy Plus Exercise for Older People With Chronic Low-back Pain: A Pragmatic Cluster Randomised Controlled Trial

Chronic Low Back Pain (CLBP)
The Hong Kong Polytechnic University100 enrolled1 locationNCT07211464
Recruiting
Not Applicable

Lumber Stabilization Exercise Versus Back Endurance Exercise Among Female University Students

Chronic Low Back Pain (CLBP)
Cairo University60 enrolled1 locationNCT07163117
Recruiting
Not Applicable

Acute Effect of Isometric Excercise on Pain Sensitivity in Adults With Chronic Low Back Pain

Chronic Low Back Pain (CLBP)
Taif University90 enrolled1 locationNCT06963658
Recruiting
Not Applicable

Art Therapy for Adults With Chronic Low Back Pain

Chronic Low Back Pain (CLBP)
The Hong Kong Polytechnic University30 enrolled2 locationsNCT07141069