RecruitingNot ApplicableNCT07059871

A Study of Silkworm Pupa Powder Intervention in the Nutritional Status of Patients With Alzheimer's Disease.

A Prospective, Double-blind, Randomized Controlled Clinical Study of Silkworm Pupa Powder Intervention in the Nutritional Status of Patients With Alzheimer's Disease


Sponsor

Zhejiang Hospital

Enrollment

200 participants

Start Date

Nov 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if silkworm pupa powder works to improve the nutritional status of Alzheimer's disease patients. The main questions it aims to answer are: * Does silkworm pupa powder evaluate the effectiveness of silkworm pupae in improving sarcopenia, frailty and quality of life in AD patients? * Does silkworm pupa powder improve cognitive function in AD patients? Researchers will compare silkworm pupa powder to a placebo (a look-alike substance that contains no drug) to see if silkworm pupa powder works to improve the nutritional status of Alzheimer's disease patients. Participants will: * Take drug silkworm pupa powder or a placebo every day for 3 months. * Visit the clinic once every 4 weeks for checkups and tests. * Keep a diary of their daily consumption.


Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether silkworm pupa powder — a high-protein food supplement — can improve the nutritional status and possibly slow cognitive decline in patients with Alzheimer's disease who are at risk of malnutrition. **You may be eligible if...** - You are between 50 and 90 years of age - You have been diagnosed with probable Alzheimer's disease based on current guidelines - You have mild to moderate Alzheimer's symptoms (MMSE score between 10 and 26) - You are male, or you are a postmenopausal female without childbearing potential - You have at least a primary school level of education - You have a caregiver who can help monitor your health and ensure you take the supplement **You may NOT be eligible if...** - You have severe Alzheimer's disease or very low cognitive scores - You are allergic to silkworm or related insects - You have serious conditions affecting your ability to eat or absorb nutrients - You are a premenopausal woman with childbearing potential - You have other major illnesses that could confound the results Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTSilkworm pupa powder

Silkworm pupa powder, 2 times a day, two packets (12\*2 g) each time, take with warm water, before meals, for three months

DIETARY_SUPPLEMENTPlacebo

Placebo, 2 sachets (12\*2 g) twice a day, with warm water, before meals, for three months


Locations(1)

Zhejiang Hospital

Hangzhou, Zhejiang, China

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NCT07059871


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