Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes

This study is investigating how 24 hours without sleep affects blood markers associated with Alzheimer's disease risk in healthy young adults, and whether this effect differs based on a person's APOE gene type (a genetic factor linked to Alzheimer's risk). Understanding how sleep loss influences these biomarkers may shed light on the connection between poor sleep and dementia risk. You may be eligible if you are 18 to 40 years old, healthy and on no medications, sleep 7 to 9 hours per night with good sleep quality, and score above 28 on a standard cognitive screening test. Participation involves one night of total sleep deprivation under supervised conditions, with blood samples collected before and after. This summary was prepared using AI to help patients understand this research.