RecruitingNot ApplicableNCT07085754
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
Sponsor
Yuhui Qiu
Enrollment
60 participants
Start Date
Aug 8, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.
Eligibility
Min Age: 18 YearsMax Age: 40 Years
Inclusion Criteria5
- Age 18-40 years, gender not limited
- Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
- Cognitively normal (Mini-Mental State Examination (MMSE) score \> 28)
- Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
- Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study
Exclusion Criteria9
- Presence of day-night sleep reversal
- Shift work within the past 6 months
- Travel across time zones or experience of jet lag within the past three weeks
- Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \[or 8 g\] of pure alcohol)
- Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation
- Family history of early-onset dementia
- Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50
- Female participants who are currently pregnant or breastfeeding
- Individuals who need to drive or operate vehicles or machinery during the study period
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Interventions
BEHAVIORALSleep Deprivation
Sleep deprivation for up to 24 hours with no naps or other sleep periods
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07085754
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