RecruitingNCT07088874

Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study

Sponsor

Peking University First Hospital

Enrollment

60 participants

Start Date

Aug 2, 2025

Study Type

OBSERVATIONAL

Conditions

Acute Kidney Injury Biomarker Nephrectomy

Summary

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates new blood and urine biomarkers (biological indicators) that may predict acute kidney injury after kidney removal surgery (radical nephrectomy). The goal is to identify early warning signs so doctors can intervene sooner. **You may be eligible if...** - You are 18 or older - You are scheduled for a unilateral radical nephrectomy (removal of one kidney) **You may NOT be eligible if...** - You only have one kidney - You have severe pre-existing chronic kidney disease (stage G4 or G5, meaning GFR less than 30) - Your tumor invades a major blood vessel (vena cava) requiring additional complex surgery - You have other conditions that could significantly affect kidney function results Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital

Beijing, Beijing Municipality, China

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NCT07088874

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