Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage
Comparison Between the Use of Aromatase Inhibitor Before Misoprostol and Use of Misoprostol Alone in Medical Termination of Miscarriage
Aswan University
70 participants
Jul 10, 2025
INTERVENTIONAL
Conditions
Summary
Abortion is one of the most common complications of pregnancy. Missed abortion is a type of abortions, occurs in 15%-20% of clinically diagnosed pregnancies and is defined as the retention of pregnancy products in the uterus for several days or weeks after death of the fetus.
Eligibility
Inclusion Criteria5
- Missed or anembryonic pregnancy.
- Gestational age from 4 weeks to 26 weeks of pregnancy (confirmed by ultrasound scanning on first day of admittance).
- Hemoglobin level more than 9g/l.
- Closed cervix.
- No product of conception in the cervical canal.
Exclusion Criteria7
- Previous attempt to terminate the pregnancy.
- Molar pregnancy
- Abnormal uterine lesions such as fibroids or congenital mal formations.
- Pregnancy despite of intrauterine contraceptive device.
- Medical disorders as cardiac, renal or hemorrhagic diseases.
- BMI more than 35 kg/m2.
- Known hypersensitivity to any of the medication used.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
to determine the effect of Letrozole as a premedication before misoprostol treatment used to induce missed miscarriage.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07109947