RecruitingNot ApplicableNCT07111169

Neuromodulation and Attention Deficits in MDD

Selective Attention Deficits and Neuromodulation in Major Depressive Disorder: Using EEG and MRI-guided iTBS Study


Sponsor

University of Electronic Science and Technology of China

Enrollment

60 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Multimodal study (Behavior, TMS, EEG) combining a sham-controlled intermittent theta burst stimulation (iTBS) intervention with an additional-singleton task and EEG to evaluate whether left dorsolateral prefrontal cortex (DLPFC) stimulation enhances cognitive control and modulates maladaptive attention processes in MDD and whether the effects are influenced by neuronavigated versus manual (Beam F3 method) localization of the stimulation site.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a type of brain stimulation called iTBS (intermittent theta burst stimulation, a form of repetitive magnetic brain stimulation) can help with attention problems in people with major depressive disorder (MDD). Researchers will also study healthy volunteers for comparison. **You may be eligible if...** - You are between 18 and 55 years old - You are right-handed - You have normal or corrected vision - For MDD participants: you meet clinical criteria for major depressive disorder, and your medication (if any) has been stable for at least one month - For healthy controls: you have no history of psychiatric or neurological disorders **You may NOT be eligible if...** - You have another severe mental health diagnosis (such as schizophrenia, bipolar disorder, or a neurodevelopmental disorder) - You are at high risk for suicide - You have received brain stimulation therapy or psychotherapy in the past 6 months - You have metal implants, claustrophobia, or other conditions that prevent MRI scanning (for the active stimulation group) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEintermittent theta burst stimulation (iTBS) intervention

iTBS protocol: Intervention with an 80-120% resting threshold was used. In the active group, the left dlPFC was selected as the stimulation site and a stimulation protocol with iTBS parameters was given. This was a neuro-modulation protocol of excitatory sequences, with theta burst stimulation at 50 Hz, repeated at 5 Hz, stimulation for 2 s with an interval of 8 s, for a total of 1,800 pulses, with a treatment time of about 20 min/session, two sessions per day, with a15-30 min rest between sessions, and five consecutive days of treatment per week, with a rest of 2 days, and two weeks of treatment.


Locations(1)

The Clinical Hospital of Chengdu Brain Science Institute, Chengdu Fourth People's Hospital, Jiujiang Branch (Chengdu Mental Health Center)

Chengdu, Sichuan, China

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NCT07111169


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