Intrapleural Ropivacaine Infusion in Cardiac Surgery
Intrapleural Ropivacaine Infusion in Cardiac Surgery: Randomized Double-blind Controlled Study
Saint Petersburg State University, Russia
116 participants
Oct 22, 2025
INTERVENTIONAL
Conditions
Summary
For many patients, a primary source of postoperative pain following cardiac surgery is the presence of pleural drains, which the surgeon places at the end of the operation and maintains for 1 to 3 days. One promising method of pain management after cardiac surgery is interpleural analgesia, particularly when traditional analgesic methods, such as systemic opioids or epidural anesthesia, may be limited due to the risk of complications. Interpleural analgesia involves the introduction of local anesthetics directly into the pleural cavity through drainage tubes placed after cardiac surgery. This method targets pain receptors in the chest area, providing effective analgesia without significant systemic effects. Several clinical studies have confirmed the safety and efficacy of intrapleural administration of anesthetics after thoracic surgery. The aim of this randomised double-blind placebo controlled study is to test the hypothesis that, in patients after cardiac surgery, the quality of recovery from anesthesia with intrapleural use of ropivacaine is superior to that with a placebo.
Eligibility
Inclusion Criteria4
- Scheduled cardiac surgery using a standard median sternotomy.
- Planned opening of the pleural cavities.
- Age more than 18 years.
- Signed informed consent to participate in the study.
Exclusion Criteria2
- Contraindications for ropivacaine
- Redo surgery
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Interventions
The patient will receive 0.2% ropivacaine (20.0 ml) into the pleural cavity intraoperatively before sternal closure. A continuous infusion of 0.2% ropivacaine will be administered through a microcatheter into the drained pleural cavity, with titration of the infusion rate. The initial infusion rate is set at 10 ml/hour.
The patient will receive 20.0 ml of a 0.9% sodium chloride solution into the pleural cavity intraoperatively, prior to sternal closure. A continuous infusion of 0.9% sodium chloride solution will then be administered through a microcatheter into the drained pleural cavity. The initial infusion rate is set at 10 ml/hour.
Locations(2)
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NCT07116343