Sex Differences in NMDA-enhancing Treatment of Schizophrenia

This study is testing whether a medication that boosts NMDA receptor activity in the brain can improve the negative symptoms of schizophrenia (such as low motivation, flat emotions, and social withdrawal), and whether the treatment works differently in men and women. **You may be eligible if...** - You have a diagnosis of schizophrenia - You have been mentally stable for at least 6 months - Your main ongoing symptoms are negative symptoms (low energy, flat affect, withdrawal) rather than hallucinations or delusions - You are on a stable dose of antipsychotic medication **You may NOT be eligible if...** - Your schizophrenia is primarily characterized by active positive symptoms (e.g., hallucinations) - You have unstable medical conditions - You are pregnant or breastfeeding - You have certain neurological conditions Talk to your doctor to see if this trial is right for you.