Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
A Comparative Study Between the Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
Ain Shams University
80 participants
Sep 4, 2025
INTERVENTIONAL
Conditions
Summary
The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing elective moderate invasive surgery (laparoscopic cholecystectomy).
Eligibility
Inclusion Criteria4
- Age from 20 to 60 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) Physical Status I-II.
- Undergoing elective laparoscopic cholecystectomy under general anesthesia.
Exclusion Criteria7
- Refusal of participation in the study by patients.
- Diabetes (type I or II), endocrine system, and immune system diseases.
- Chronic infection and sepsis.
- Cardiac condition as classified bythe New York Heart Association (NYHA) \> class II.
- Hepatic disease: INR \> 1.5, and/or albumin \< 2.5 g/dL.
- Renal disease: glomerular filtration rate (GFR) \< 85 ml/min.
- Mental and neurological disorders.
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Interventions
Patients will receive general anesthesia and maintenance by isoflurane.
Patients will receive general anesthesia and maintenance by sevoflurane.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07152912