RecruitingNCT07154394

Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Investigation of Cardiac Amyloid Deposits as a Cause of Cardiac Dysfunction in Alzheimer's Disease (Untersuchung Von Kardialen Amyloidablagerungen Als Ursache Einer Funktionseinschränkung Des Herzens Bei Alzheimer Demenz)

Sponsor

University Hospital, Essen

Enrollment

15 participants

Start Date

Aug 15, 2022

Study Type

OBSERVATIONAL

Conditions

Mild Cognitive Impairment Cardiac Amyloidosis Dementia Alzheimer Type

Summary

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
No contraindications to undergo an MRI examination
No contraindications to undergo an Amyloid PET scan

Exclusion Criteria3

Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
Patients with pronounced cardiac preconditions
Pregnant and breastfeeding women