RecruitingNCT07154394

Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Investigation of Cardiac Amyloid Deposits as a Cause of Cardiac Dysfunction in Alzheimer's Disease (Untersuchung Von Kardialen Amyloidablagerungen Als Ursache Einer Funktionseinschränkung Des Herzens Bei Alzheimer Demenz)

Sponsor

University Hospital, Essen

Enrollment

15 participants

Start Date

Aug 15, 2022

Study Type

OBSERVATIONAL

Conditions

Mild Cognitive Impairment Cardiac Amyloidosis Dementia Alzheimer Type

Summary

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether abnormal protein deposits (amyloid) are found in the hearts of people with Alzheimer's disease — and whether these deposits might contribute to heart problems. Participants will undergo brain PET scans and heart MRI as part of their routine Alzheimer's evaluation. **You may be eligible if...** - You are already scheduled to have a brain amyloid PET scan as part of your Alzheimer's disease workup - You have no contraindications to MRI or amyloid PET scans **You may NOT be eligible if...** - You have been diagnosed with vascular dementia or another clearly confirmed cause of dementia (e.g., stroke, vitamin deficiency, thyroid problem, alcohol-related) - You have significant pre-existing heart conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.