RecruitingNot ApplicableNCT07165106

Effects of Resistance and Aerobic Exercises on Walking and Sarcopenic Parameters in Parkinson's Disease

Comparison of the Effects of Resistance and Aerobic Exercises Added to Conventional Rehabilitation Program on Walking and Sarcopenic Parameters in Patients With Sarcopenic Parkinson's Disease

Sponsor

Ahi Evran University Education and Research Hospital

Enrollment

30 participants

Start Date

Sep 10, 2025

Study Type

INTERVENTIONAL

Conditions

Sarcopenia PARKINSON DISEASE (Disorder)

Summary

The aim of this study was to investigate the effects of resistance and aerobic exercises on the following outcomes in patients with sarcopenic Parkinson's disease: Timed Up and Go Test (TUG), gait speed, Short Physical Performance Battery (SPPB), handgrip strength, Five-Times Sit-to-Stand Test, and MDS-UPDRS Part II scores.

Eligibility

Min Age: 40 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study compares resistance exercise (strength training) versus aerobic exercise (cardio) in people with Parkinson's disease who also have sarcopenia — a condition where muscle mass and strength are significantly reduced — to see which type of exercise better improves walking ability and muscle health. **You may be eligible if...** - You are 40 to 85 years old - You have a clinical diagnosis of Parkinson's disease - You also have sarcopenia (confirmed by established criteria) - Your Parkinson's is at a moderate stage (Hoehn & Yahr stage 2 or 3) - You can provide written consent **You may NOT be eligible if...** - You do not meet the sarcopenia criteria - Your Parkinson's is at stage 1 (mild) or stage 4 (severe) - You have had cancer, epilepsy, or a heart pacemaker - You have heart failure or uncontrolled high blood pressure - You have orthopedic, breathing, or balance problems that limit exercise Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic Exercise

Participants in this group will receive conventional rehabilitation in combination with supervised treadmill-based aerobic exercise three times per week for 6 weeks. Each exercise session will consist of a 5-minute warm-up, a 15-minute main exercise phase, and a 5-minute cool-down. Walking speed will be individualized based on participant tolerance and progressively increased under clinical supervision. Exercise intensity will be monitored using the modified Borg Rating of Perceived Exertion (scale 6-20). Weeks 1-2: Main exercise at Borg 10-11 (light-moderate). Weeks 3-4: Main exercise at Borg 11-12 (moderate). Weeks 5-6: Main exercise at Borg 12-13 (moderate-high). Cardiorespiratory responses will be monitored during all sessions, and treadmill speed will be gradually adjusted in accordance with improvements in exercise tolerance while maintaining safety.

BEHAVIORALResistance Exercise

Participants in this arm will receive conventional rehabilitation combined with supervised resistance training using elastic bands, 3 times per week for 6 weeks. Exercises target major upper- and lower-limb and hip muscles. Each exercise is performed for 3 sets of 10 repetitions with 60-90 seconds rest. Initial band tension is set at the highest tolerable level and progressively increased. The program includes shoulder press, biceps curl, triceps extension, seated leg extension, calf raise, and lateral band walk. All sessions are supervised, emphasizing correct posture, controlled full range of motion, and avoidance of compensatory movements. Patients are guided with verbal and visual cues when necessary.

BEHAVIORALConventional Rehabilitation

Participants in this group will receive conventional rehabilitation only, 5 days per week, 1 hour per day, for 6 weeks. The program includes upper and lower limb range of motion exercises, stretching, walking practice, balance and coordination training, proprioceptive exercises, posture correction, obstacle crossing, and turning in place. All sessions are delivered under clinical supervision, with emphasis on correct posture, safety, and full range of motion