A Phase Ib Trial of Combined Febuxostat and Inosine Therapy in Patients With Parkinson's Disease

This trial is testing a combination of two drugs — febuxostat (a gout medication) and inosine (a natural compound) — to see if they can slow the progression of Parkinson's disease by raising uric acid levels in the blood, which may protect brain cells. **You may be eligible if...** - You are between 18 and 80 years old with a diagnosed Parkinson's disease - Your Parkinson's is mild to moderate (Hoehn-Yahr stage 1–3) - You have been on stable Parkinson's medications for at least 3 months - Your memory and thinking are intact (MMSE score 24 or higher) **You may NOT be eligible if...** - You need almost total help with daily activities or cannot walk or stand - You take certain medications including azathioprine, mercaptopurine, or rosuvastatin - You used gout medications (febuxostat, allopurinol, topiroxostat) in the last 3 months - You already take inosine supplements - You have had surgery for Parkinson's disease - Your kidney or liver tests are significantly abnormal Talk to your doctor to see if this trial is right for you.