Electrophysiology-based DBS Programming for PD
Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease
University of Florida
30 participants
Jan 15, 2026
INTERVENTIONAL
Conditions
Summary
Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Contacts, amplitude, pulse width, and frequency are chosen by the treating physician during a conventional monopolar review.
The contact that shows the strongest beta activity (13-30 Hz) in the local field potentials is selected for stimulation.
A multi-frequency algorithm that integrates beta, theta/alpha, finely tuned gamma, and other relevant bands is used to identify the optimal contact.
Locations(1)
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NCT07348705