RecruitingNot ApplicableNCT07348705

Electrophysiology-based DBS Programming for PD

Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease


Sponsor

University of Florida

Enrollment

30 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.


Eligibility

Min Age: 21 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new way of programming deep brain stimulation (DBS) devices for people with Parkinson's disease. Instead of using standard methods, researchers are using brain electrical signals (electrophysiology data) recorded directly by the implanted device to tailor the stimulation settings more precisely to each individual. **You may be eligible if...** - You have been diagnosed with idiopathic Parkinson's disease (standard Parkinson's, not an atypical variant) - You have had a Percept DBS device (made by Medtronic) implanted to help with movement symptoms - You are 21–89 years old - You are willing to have your device programmed at your initial programming session using this new approach **You may NOT be eligible if...** - You have atypical parkinsonism (a different condition that looks similar to PD) - You have personality or mood symptoms that would interfere with the study - You are unable to cooperate with the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEClinician-based DBS programming

Contacts, amplitude, pulse width, and frequency are chosen by the treating physician during a conventional monopolar review.

DEVICEMaximum Beta power-based DBS programming

The contact that shows the strongest beta activity (13-30 Hz) in the local field potentials is selected for stimulation.

DEVICEBroad-band electrophysiology-based DBS programming

A multi-frequency algorithm that integrates beta, theta/alpha, finely tuned gamma, and other relevant bands is used to identify the optimal contact.


Locations(1)

Norman Fixel Institute for Neurological Diseases

Gainesville, Florida, United States

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NCT07348705


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