Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Impact of Intraoperative Hemodynamic Instability on Postoperative Major Adverse Events in Cardiac Surgery Patients: A Prospective Cohort Study
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
230 participants
Apr 26, 2025
OBSERVATIONAL
Conditions
Summary
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \< 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.
Eligibility
Inclusion Criteria5
- Patients aged 18 years or older.
- Scheduled for elective cardiac surgery (CABG, Valve replacement/repair, or combined procedures).
- Surgery performed under cardiopulmonary bypass (CPB).
- Preoperative sinus rhythm.
- Signed informed consent form.
Exclusion Criteria6
- Emergency or salvage surgery.
- Off-pump coronary artery bypass grafting.
- Preoperative mechanical circulatory support (IABP, ECMO) requirement.
- Pre-existing chronic renal failure requiring dialysis (HD/PD).
- Pre-existing cognitive impairment, dementia, or history of psychiatric disorders affecting cooperation.
- Pregnancy.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07324694