Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

This study is looking at biomarkers — biological indicators — of eye surface damage in people with glaucoma who are using prescription eye drops to control their eye pressure. The goal is to better understand how these medications affect the surface of the eye. **You may be eligible if...** - You have open-angle glaucoma or suspected open-angle glaucoma - You use glaucoma eye drops (up to 3 per day), including one nightly preserved prostaglandin analog - You have been on your current eye drop regimen for at least 6 months - You have minor corneal surface damage (erosions visible on exam) - You adhere well to your eye drop schedule (missing drops less than 20% of the time) **You may NOT be eligible if...** - You have a retinal disease (such as wet macular degeneration or diabetic retinopathy) - You use topical or systemic immune-suppressing medications (like steroids or cyclosporine) - You use preservative-free eye drops - You have a history of recurrent eye infections or corneal transplant - You have other significant eye conditions Talk to your doctor to see if this trial is right for you.