Cannabis Reduction and Functional Outcomes
Prospective Changes in Patient-reported and Objective Functioning Following Reduction of Cannabis Use
Medical University of South Carolina
176 participants
Mar 13, 2026
INTERVENTIONAL
Conditions
Summary
This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in urinary cannabinoids. The study aims to assess improvements in cannabis-related problems, sleep, cognitive performance, CUD severity, and quality of life.
Eligibility
Inclusion Criteria5
- Age 18+
- Urinary cannabinoid level ≥ 50 ng/mL
- DSM-5 diagnosis of CUD (mild, moderate, or severe)
- Willingness to attempt cannabis reduction
- Completion of Intake Visit
Exclusion Criteria5
- Serious medical/psychiatric conditions
- Pregnancy or breastfeeding
- Use of cannabis in past 30 days was for medical purposes only
- Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition
- Cognitive or understanding difficulties, as evidenced by inability to pass informed consent quiz
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Interventions
Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.
Participants will receive one therapist-led motivational interviewing/goal setting session followed by 7 sessions of computerized CBT4CBT.
Patients will receive contingent reinforcers (financial incentives for reduction in urinary cannabinoids).
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07218471