RecruitingPhase 4NCT07221617
Oral Methadone in Cardiac Surgery
Oral Methadone In Cardiac Surgery
Sponsor
Mayo Clinic
Enrollment
100 participants
Start Date
Jan 13, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Eligibility
Min Age: 18 Years
Inclusion Criteria1
- Undergoing elective cardiac surgery
Exclusion Criteria9
- Chronic pain requiring opioid medications as an outpatient
- Opioid use disorder on medication assistance treatment
- Prolonged QTc >500ms
- Chronic kidney disease with eGFR < 30mL/min
- Documented cirrhosis
- Intolerance to methadone
- Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery
- Pregnancy at the time of surgery
- Subsequent surgeries after index surgery
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Interventions
DRUGMethadone, oral
Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room
DRUGMethadone, intravenously
Patients will receive 0.3mg/kg methadone intravenously after induction of general anesthesia
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07221617
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