RecruitingNCT07235111

Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases

Sponsor

Ospedale Policlinico San Martino

Enrollment

1,200 participants

Start Date

Feb 28, 2025

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Parkinson Disease FTD Young-onset Dementia MCI ALS (Amyotrophic Lateral Sclerosis)

Summary

The study aims to use 'omics' sciences, employing the most advanced technologies currently available, in order to identify pathogenic genomic variants, proteins and/or altered molecular pathways in neurodegenerative diseases and to obtain a new and more complete characterisation of subjects affected by the neurodegenerative diseases under study. Thanks to the integration of genomic, gene expression (transcriptomic and epigenomic), protein and metabolic data and clinical data, the study also aims to identify new markers for the diagnosis, prognosis, also in terms of response to therapy, and monitoring of neurodegenerative diseases. The study involves the enrolment of at least 1.200 individuals with neurodegenerative disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting biological samples (such as blood or tissue) from people with neurodegenerative diseases — conditions where nerve cells in the brain or nervous system progressively break down over time, such as Alzheimer's disease, Parkinson's disease, ALS, or Huntington's disease — to identify the biological markers and underlying mechanisms driving these illnesses. The findings may help researchers develop better diagnostic tools and future treatments. **You may be eligible if...** - You have been diagnosed with a neurodegenerative disease (any condition involving progressive deterioration of nerve cells or brain function) - You are willing to provide biological samples as part of the study **You may NOT be eligible if...** - You do not have a confirmed diagnosis of a neurodegenerative disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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