RecruitingNot ApplicableNCT07237230

Clinical Study to Evaluate the Safety and Efficacy of γδ T Cells for the Prevention of Relapse After Allogeneic Transplantation in Patients With High-risk Acute Myeloid Leukemia

Clinical Study Protocol to Evaluate the Safety and Efficacy of γδ T Cells for the Prevention of Relapse After Allogeneic Transplantation in Patients With High-risk Acute Myeloid Leukemia


Sponsor

Donghua Zhang

Enrollment

40 participants

Start Date

Jul 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an investigator-initiated clinical trial evaluating the safety and efficacy of allogeneic γδ T cell infusion for relapse prevention in high-risk acute myeloid leukemia patients after transplantation.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether infusions of specially prepared immune cells called gamma-delta T cells — from the donor — can help prevent leukemia from coming back after a bone marrow transplant (allogeneic stem cell transplant) in people with high-risk acute myeloid leukemia (AML), a fast-growing blood cancer. **You may be eligible if...** - You are between 18 and 65 years old - You have acute myeloid leukemia (AML) with high-risk factors for relapse - You are planning to undergo or have recently had an allogeneic stem cell transplant (a transplant using cells from a donor) **You may NOT be eligible if...** - You do not have high-risk features for relapse - You have significant organ dysfunction - You are not a candidate for transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALallogeneic γδ T cell infusion

allogeneic γδ T cell infusion


Locations(1)

Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, China

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NCT07237230


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