RecruitingNCT07253038

Evaluation of Three Tests to Assess Social Cognition in Huntington Disease

The Social-HD Study: A Cross-Sectional Observational Study of Social Cognition in Early Huntington Disease


Sponsor

Region Skane

Enrollment

40 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease. Huntington disease affects motor function, psychological well-being and cognitive functions ("thinking abilities" such as paying attention, remembering and solving problems). It is also believed to affect important social functions, including the ability to understand others' intentions and emotions (social cognition). The test of interest in this study is called The Double Movie for the Assessment of Social Cognition-Multiple Choice (DMASC-MC) and will be compared to two other similar and well-known tests. The main question which the study aims to answer is: • Is DMASC-MC a useful tool for detecting problems with social functioning in adult persons with early Huntington disease? In the study, participants will meet with a medical doctor and a psychologist for assessment of different symptoms related to Huntington disease, including social functioning. Better methods for identifying problems with social functioning could help persons with Huntington disease and their families in mainly two ways. Firstly, it could increase their understanding of how the disease has affected them. Secondly, a better understanding of these problems could lead to better recommendations and interventions from medical teams, which would also benefit persons with Huntington disease and families.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates three tests designed to measure "social cognition" — the ability to understand and read emotions, intentions, and social cues — in people with Huntington's disease (a genetic condition that causes progressive nerve cell breakdown in the brain) compared to healthy controls. No treatment is being tested. **You may be eligible if...** - Huntington's disease group: You have a clinical diagnosis of HD and your genetic test shows 40 or more CAG repeats - Control group: You have no family history of HD or have a confirmed negative pre-symptomatic genetic test for HD - You speak Swedish as your native language - Your memory and general cognition are within study range (MoCA or MMSE ≥19) **You may NOT be eligible if...** - You have dementia or severe cognitive impairment (MMSE or MoCA below 19) - You have another neurological condition - You have active psychosis - You have an active substance use disorder (alcohol or drugs) - You have severe vision or hearing problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(1)

Skane University Hospital, Region Skane

Lund, Sweden

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07253038


Related Trials