RecruitingNCT03233646

Retinal Imaging in Neurodegenerative Disease

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

Sponsor

Duke University

Enrollment

2,000 participants

Start Date

Jul 20, 2017

Study Type

OBSERVATIONAL

Conditions

Traumatic Brain Injury Huntington Disease Neuro-Degenerative Disease Multiple Sclerosis Post Traumatic Stress Disorder Down Syndrome Mild Cognitive Impairment Frontotemporal Dementia Alzheimer s Disease Amyotrophic Lateral Sclerosis(ALS)Parkinson's Disease Lewy Body Dementia APOE-4 Positive Concussion Normal Cognition

Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
Adults without neurodegenerative disease

Exclusion Criteria2

Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
Eyes that have had intraocular surgery, other than cataract surgery.