RecruitingNCT03233646

Retinal Imaging in Neurodegenerative Disease

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

Sponsor

Duke University

Enrollment

2,000 participants

Start Date

Jul 20, 2017

Study Type

OBSERVATIONAL

Conditions

Traumatic Brain Injury Huntington Disease Neuro-Degenerative Disease Multiple Sclerosis Post Traumatic Stress Disorder Down Syndrome Mild Cognitive Impairment Frontotemporal Dementia Alzheimer s Disease Amyotrophic Lateral Sclerosis(ALS)Parkinson's Disease Lewy Body Dementia Concussion APOE-4 Positive Normal Cognition

Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using a special eye-scanning camera to look at the back of the eye (the retina) to see if changes there can help detect or track brain diseases like Alzheimer's, Parkinson's, multiple sclerosis, and other conditions. **You may be eligible if...** - You are an adult who has been diagnosed with a neurological or brain-related disease (such as Alzheimer's, Parkinson's, MS, ALS, TBI, PTSD, Down Syndrome, or similar) - OR you are a healthy adult with no neurological disease (to serve as a comparison) **You may NOT be eligible if...** - You are unable to cooperate with the eye exam or complete the testing - You have had eye surgery other than cataract surgery, or have a condition that would interfere with getting a clear image of the retina Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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