RecruitingPhase 3NCT07256158

PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma

PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma: a Randomized, Phase III, Non-inferiority studY (PRIORITY Study)

Sponsor

Fondazione Italiana Linfomi - ETS

Enrollment

518 participants

Start Date

Jul 10, 2026

Study Type

INTERVENTIONAL

Conditions

Hodgkin Lymphoma

Summary

The final analysis of GHSG HD11 study (not PET driven) showed that 30 Gy IFRT still remains the standard dose after 4 ABVD. Early PET negativity might allow safe radiation de-escalation in patients achieving a metabolic complete response after 2 ABVD. The aim of Priority trial is to explore whether radiotherapy could be safely deescalated to 20 Gy without loss of efficacy in patients treated with four cycles of ABVD who achieved complete metabolic response after the first two cycles.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying 20 Gy Involved site radiotherapy and 30 Gy Involved site radiotherapy for people with hodgkin lymphoma. The study is currently recruiting participants at 38 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATION20 Gy Involved site radiotherapy

Total dose 20 Gy Involved site radiotherapy

RADIATION30 Gy Involved site radiotherapy

Total dose 30 Gy Involved site radiotherapy

Locations(38)

A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia

Alessandria, Italy

A.O.R.N. G Moscati - U.O.C. Ematologia e Terapie cellulari avanzate

Avellino, Italy

IRCCS Centro Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlati

Aviano, Italy

ASST Papa Giovanni XXIII - S.C. Ematologia

Bergamo, Italy

Clinica Humanitas Gavazzeni - U.O. Oncologia Medica

Bergamo, Italy

ASST Spedali Civili - S.C. Ematologia

Brescia, Italy

ARNAS "Brotzu" P.O. Businco - S.C. Ematologia e TMO

Cagliari, Italy

I.R.C.C.S. Istituto di Candiolo - FPO

Candiolo, Italy

ARNAS Garibaldi - U.O.C. Ematologia

Catania, Italy

A.O. S. Croce e Carle - S.C. Ematologia

Cuneo, Italy

A.S.L. Toscana Centro - SOC Oncoematologia

Florence, Italy

Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia

Florence, Italy

IRCCS Policlinico S. Martino - U.O. Ematologia e terapie cellulari

Genova, Italy

ASL Latina Ospedale S. Maria Goretti - UOC Ematologia con trapianto

Latina, Italy

ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia

Milan, Italy

IRCCS Fondazione Istituto Nazionale Tumori - S.C. Ematologia

Milan, Italy

A.O.U. Ospedale Maggiore della Carità - S.C.D.U. Ematologia

Novara, Italy

A.O.U. di Padova - U.O.C. Ematologia

Padova, Italy

I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1

Padova, Italy

A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia

Palermo, Italy

IRCCS Fondazione Policlinico S. Matteo - S.C. Ematologia 1

Pavia, Italy

A.O. Ospedale S. Maria della Misericordia - Ematologia

Perugia, Italy

AUSL di Piacenza Ospedale Guglielmo da Saliceto - U.O.C. Ematologia e centro trapianti

Piacenza, Italy

AUSL di Ravenna Osp. S. Maria delle Croci - U.O.C. Ematologia

Ravenna, Italy

AUSL IRCCS Arcispedale S. Maria Nuova - S.C. Ematologia

Reggio Emilia, Italy

A.O.U. Policlinico Umberto I - U.O.C Ematologia

Roma, Italy

A.O.U. Sant'Andrea - U.O.C. Ematologia

Roma, Italy

Fondazione Policlinico Campus Bio-Medico - U.O.C. Ematologia e trapianto di cellule staminali

Roma, Italy

IRCCS Humanitas - U.O. Ematologia

Rozzano, Italy

IRCCS Fondazione Casa Sollievo della Sofferenza - UOC Ematologia e Trapianto di Cellule Staminali Ematopoietiche

San Giovanni Rotondo, Italy

A.O.U. Senese - U.O.C. Ematologia

Siena, Italy

A.O. Santa Maria - S.C. Oncoematologia

Terni, Italy

A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U

Torino, Italy

A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia

Torino, Italy

ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia

Treviso, Italy

A.S.U. Giuliano Isontina - S.C. Ematologia

Trieste, Italy

A.S.U. Friuli Centrale - Clinica Ematologica

Udine, Italy

A.O.U.I. di Verona - U.O.C. Ematologia

Verona, Italy

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NCT07256158

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