RecruitingNCT07259499

Predictors of Emergency Department Use in Frail Patients

Towards an Integrated Care System for the Assistance of Patients With Chronic Diseases, Multimorbidity, Frailty, and Polypharmacy

Sponsor

University of Pisa

Enrollment

110 participants

Start Date

Nov 19, 2023

Study Type

OBSERVATIONAL

Conditions

Elderly Frailty Alzheimer s Disease Vascular Dementia Emergency Department Visits Autonomy

Summary

When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed. While cognitive impairment is a known clinical risk factor, biomarkers of most prevalent dementias have been scarcely investigated as possible ED use predictors. Within this context, this prospective study aims at exploring whether plasma phospho-tau181 and cerebrovascular burden can predict ED use at 6 months in elderly non-autonomous patients, irrespective of frailty.

Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at which factors — including blood tests and brain scans — can predict whether older adults with reduced independence are likely to visit the emergency department in the near future. **You may be eligible if...** - You are over 64 years old - You are fluent in Italian - You have lost some ability to perform daily activities independently (assessed by standard questionnaires) - You have had routine blood tests and a brain MRI or CT scan in the past 6 months **You may NOT be eligible if...** - You are unable to communicate in Italian - You have not had recent blood tests or brain imaging - You live fully independently without any loss of daily function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPlasma phosphorylated Tau 181

Plasma will be collected in dipotassium EDTA tubes at recruitment and centrifugated at 1800-2000xg for 10 minutes within a short data frame. Plasma will be subsequently aliquoted and stored at -80°C. Immediately prior to analysis, samples will be thawed at room temperature, vortexed, and centrifuged. Plasma p-tau181 concentrations will be then quantified using a fully automated chemiluminescent enzyme immunoassay on the LUMIPULSE G600II system, in accordance with the manufacturer's instructions.

Locations(1)

Azienda Ospedaliera Universitaria Pisana

Pisa, Pisa, Italy

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NCT07259499

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