RecruitingNot ApplicableNCT07260032

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

Using Advanced Imaging to Determine the Benefits of Exercise on Cardiovascular Risk in PTSD

Sponsor

Massachusetts General Hospital

Enrollment

10 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Disease PTSD Cardiovascular Disease Risk Factors

Summary

The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated risk for artery disease.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

Age 18-65 years
Trauma exposure
PTSD symptoms
Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or increased risk for atherosclerotic CVD (i.e., \>2 of hypertension, diabetes mellitus, hyperlipidemia, and active smoking)
Ability to understand and sign informed consent

Exclusion Criteria14

History of stroke, brain surgery, or seizure
Use of certain CVD medications (e.g., beta-blockers, high-intensity statins \[e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg\], PCSK-9 inhibitors)
Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)
Unstable blood pressure or cardiac arrhythmia
Currently in a supervised or graduated exercise program
Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy
Moderate/severe alcohol/substance use disorder
Current mania/psychosis
Weight \>300 lbs.
Claustrophobia
Pregnancy
Metal implants
Uncontrolled hyperglycemia (HgbA1c\>7.5%)
Subjects who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months