RecruitingNot ApplicableNCT07384143

Cognitive Recovery Via Sensor-based Robotic Upper Limb Rehabilitation in Neurological Disorders

Exploring Cognitive Recovery: the Impact of Sensor-based Robotic Rehabilitation in Neurological and Neurodegenerative Disorders

Sponsor

IRCCS Centro Neurolesi Bonino Pulejo

Enrollment

189 participants

Start Date

Feb 11, 2025

Study Type

INTERVENTIONAL

Conditions

Stroke Multiple Sclerosis PARKINSON DISEASE (Disorder)Neurological Disorders

Summary

The goal of this clinical trial is to learn if sensor-based robotic upper limb rehabilitation can improve cognitive and motor functions in adults with neurological and neurodegenerative disorders, including Parkinson's disease, multiple sclerosis, and stroke. The main questions it aims to answer are: Does sensor-based robotic rehabilitation improve cognitive functions such as attention, memory, and executive functions? Does this rehabilitation lead to better motor recovery and daily functioning compared to conventional therapy? Researchers will compare the experimental group receiving robotic rehabilitation with cognitive tasks to the control group receiving conventional therapy to see if the robotic approach leads to greater improvements in both cognitive and motor outcomes. Participants will: Receive upper limb rehabilitation using robotic devices and virtual reality-based exercises or conventional therapy Complete a series of neuropsychological assessments before and after the intervention to measure cognitive changes Complete motor function tests before and after the intervention to evaluate physical improvements Participate in 25 training sessions, 2-3 times per week, each lasting 60 minutes

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how robotic upper-limb rehabilitation devices, guided by sensors, can help improve both arm movement and cognitive function in people with neurological conditions such as stroke. Different robotic systems will be used based on the severity of arm impairment. **You may be eligible if...** - You are between 18 and 75 years old - You have arm weakness from a neurological condition (such as stroke) - Your arm function score (FMA-UL) places you in a range appropriate for robotic therapy - Your cognitive assessment (MoCA) score is 20 or below, indicating mild to moderate impairment **You may NOT be eligible if...** - You have severe cognitive problems that prevent participation - You have significant behavioral disorders - You have severe sensory loss or other sensory disorders that would interfere with the therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICESensor-Based Robotic Rehabilitation with Cognitive Tasks (SBRR)

Participants receive upper limb rehabilitation using sensor-based robotic devices (e.g., Motore, Armeo Senso, Hand Tutor, Armeo Power, Armeo Spring, Pablo, Amadeo, Diego) combined with virtual reality exercises. The intervention integrates cognitive tasks-such as attention, memory, and executive function exercises-simultaneously with motor training. Therapy is personalized in real-time according to each patient's performance, adjusting difficulty, intensity, and assistance levels to maximize both cognitive and motor recovery.

DEVICEStandard Conventional Therapy

Participants receive traditional upper limb rehabilitation, including standard physiotherapy exercises without robotic assistance or integrated cognitive tasks. Therapy focuses on motor recovery using conventional methods, such as repetitive movement exercises, range of motion, and functional tasks, but does not adapt in real-time to patient performance and does not include concurrent cognitive stimulation.

Locations(1)

IRCCS Centro Neurolesi Bonino-Pulejo

Messina, Maine, Italy

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NCT07384143

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