RecruitingNot ApplicableNCT07386548

Biologic Injection For Adults With Lumbar Disc Herniation

Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial


Sponsor

Weill Medical College of Cornell University

Enrollment

90 participants

Start Date

Aug 30, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation. The main questions it aims to answer are: * Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)? * Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone? Participants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery. Researchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit. Participants will: * Have surgery (microdiscectomy) with or without the injection. * Complete pain and disability questionnaires at several times over 2 years. * Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health. * Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Bone Marrow Aspirate Concentrate (BMAC) for people with bone marrow aspirate concentrate, clbp - chronic low back pain, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBone Marrow Aspirate Concentrate (BMAC)

Dosage Form: Autologous intradiscal injection Dosage: 1-2 cc's Frequency: Once, during surgery Duration: N/A


Locations(1)

NewYork-Presbyterian/Weill Cornell Medical Center

Manhattan, New York, United States

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NCT07386548


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