RecruitingNot ApplicableNCT07393490

Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.

The Effect of Apneic Oxygenation of the Non-ventilated Lung on the Expression of Hypoxia-inducible Factor-1 Alpha (HIF-1α) and Interleukin-6 (IL-6) in Lung Tissue During Lung Cancer Surgery.

Sponsor

Osijek University Hospital

Enrollment

56 participants

Start Date

Jan 2, 2025

Study Type

INTERVENTIONAL

Conditions

Lung Cancer (Diagnosis)

Summary

This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery. Patients undergoing surgical resection of lung cancer often require one-lung ventilation during anaesthesia. This results in alveolar hypoxia accompanied by upregulated expression of inflammatory markers. Apneic oxygenation of the non-ventiladed lung may influence inflammatory processes and oxygenation during surgery. The aim of this study is to evaluate whether apneic oxygenation affects inflammatory markers in lung tissue and postoperative recovery in patients undergoing lung cancer surgery. The study is conducted at a single center and includes adult patients scheduled for elective lung cancer surgery. Data will be collected durig the perioperative period. The results of this study may contribute to improved anaesthetic management and patient outcomes during thoracic surgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a technique called apneic oxygenation — where oxygen is delivered to the lung not being ventilated during surgery — in people undergoing lung cancer surgery that removes a single lung segment. The goal is to see if this technique reduces the risk of oxygen loss and complications during the procedure. **You may be eligible if...** - You are 18 or older - You have lung cancer and are scheduled for surgical removal of a single lung segment (segmentectomy) - You have provided written informed consent **You may NOT be eligible if...** - You are younger than 18 - You are on long-term steroid therapy or immunosuppressive medications - You have severe lung disease (advanced COPD, severe asthma, or severe pulmonary fibrosis with significantly reduced lung function) - You have other significant conditions that would make this technique unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREApnoeic Oxygenation

Apneic oxygenation of the non-ventilated lung is applied during lung cancer surgery to maintain oxygenation and decrease inflammatory response while the lung is not mechanically ventilated.

PROCEDUREStandard Ventilation

Standard ventilation is applied during lung cancer surgery according to routine clinical practice.

Locations(1)

University Hospital Center Osijek

Osijek, Croatia

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NCT07393490

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