RecruitingNCT07413640

Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors

Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors : a Retrospective Study


Sponsor

Central Hospital, Nancy, France

Enrollment

90 participants

Start Date

Feb 2, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

Microwave ablation is a minimally invasive technique whose planning relies on manufacturer tables derived from ex vivo models that do not account for patient or tumor-specific factors. In clinical practice, the actual ablation volume often differs from the planned volume due to liver characteristics, vascular proximity, and tumor biology. This study aims to assess the variability between ablation small axis during percutaneous microwave ablation of liver lesions. The influence of patient-related (fibrosis, steatosis, portal flow) and tumor-related factors (location, histology, prior treatment) will be evaluated. Small axis and volume will be compared with volumes measured on immediate post-procedural CT and on CT/MRI at 6-12 weeks, accounting for expected tissue shrinkage.


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study analyzes factors that affect the size and shape of the destroyed tissue (ablation zone) during microwave ablation — a minimally invasive procedure that uses heat to destroy liver tumors — to improve planning and precision of the treatment. **You may be eligible if...** - You are an adult who has received microwave ablation for one or more liver lesions (tumors) - The procedure was done under CT or ultrasound guidance - You have follow-up imaging available **You may NOT be eligible if...** - You had multiple treatment cycles on the same tumor in a single session - You had repeat treatment on the same lesion - The planned treatment volume data is not available - There is no imaging done between 1 and 4 months after the procedure - The ablation zone cannot be measured on imaging (for example, due to artifacts) - There is no confirmed diagnosis of the tumor type Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

CHRU Nancy

Vandœuvre-lès-Nancy, France

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NCT07413640


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