Estradiol and Intrusive Memories
The Effect of Estradiol on the Acquisition and Consolidation of Trauma-Associated Memories
Charite University, Berlin, Germany
273 participants
Aug 19, 2024
INTERVENTIONAL
Conditions
Summary
The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.
Eligibility
Plain Language Summary
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Interventions
3mg of Estradiol Valerate pills, administred orally
Plabo pill
Locations(1)
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NCT07419594