RecruitingNot ApplicableNCT07419594

Estradiol and Intrusive Memories

The Effect of Estradiol on the Acquisition and Consolidation of Trauma-Associated Memories


Sponsor

Charite University, Berlin, Germany

Enrollment

273 participants

Start Date

Aug 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma. A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls. This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study examines how estradiol (a form of estrogen) affects the formation and intensity of intrusive memories — unwanted, distressing memories that pop into your mind involuntarily. The goal is to understand how hormones influence traumatic memory processes in healthy women. **You may be eligible if...** - You are a healthy female volunteer - You speak German at a B1 level or higher **You may NOT be eligible if...** - You have or have had a mental health disorder (as defined by DSM-5) - You have any physical illness - You take any medications except oral contraceptives - You have a history of traumatic experiences such as sexual abuse or assault - You are pregnant or breastfeeding - You currently take oral contraceptives (in some study arms) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEstradiol Valerate

3mg of Estradiol Valerate pills, administred orally

DRUGPlacebo

Plabo pill


Locations(1)

Charité - Universitätsmedizin Berlin

Berlin, State of Berlin, Germany

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NCT07419594


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