RecruitingPhase 4NCT07442006

Glycemic Variability of Combination Therapies in T2DM

A Multicenter Study to Evaluate Efficacy and Safety


Sponsor

JW Pharmaceutical

Enrollment

178 participants

Start Date

Oct 29, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Glycemic Variability of Combination Therapies in T2DM


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing different medication combinations in people with type 2 diabetes who are not achieving adequate blood sugar control despite already taking metformin and an SGLT-2 inhibitor (two common diabetes medications). Researchers are looking at how different add-on therapies affect blood sugar variability throughout the day. **You may be eligible if...** - You have type 2 diabetes - You are already taking metformin (at least 1,000 mg per day) and an SGLT-2 inhibitor (such as empagliflozin or dapagliflozin) - Your blood sugar is still not well controlled despite these medications **You may NOT be eligible if...** - You have a history of lactic acidosis or metabolic acidosis (a dangerous build-up of acid in the blood) - You have moderate to severe kidney disease (eGFR below 45) - You have severe liver problems - You have advanced heart failure (NYHA Class III or IV) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEmpagliflozin/Metformin

5/500 mg, 5/1000 mg (based on prior Metformin dose), for 12 weeks (PO, BID)

DRUGAnagliptin

100 mg, for 12 weeks (PO, BID)

DRUGMetformin

500 mg, 1000 mg (based on prior Metformin dose), for 12 weeks (PO, BID)

DRUGEmpagliflozin/Linagliptin

10/5 mg, for 12 weeks (PO, QD)


Locations(1)

The Catholic University of Korea, Bucheon St. Mary's Hospital, Principal Investigator

Seoul, South Korea

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NCT07442006


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