IMPACT 360 for Parkinson's Disease

This study (IMPACT 360) is testing a comprehensive lifestyle intervention — combining exercise, mindfulness, and diet guidance — for people with early-stage Parkinson's disease or REM sleep behavior disorder (a sleep condition that can be an early sign of Parkinson's). The program is delivered using fitness trackers, video calls, and smartphone apps. **You may be eligible if...** - You are between 40 and 85 years old - You have been diagnosed with Parkinson's disease (early stage: Hoehn and Yahr 1 or 2) OR REM sleep behavior disorder confirmed by a sleep study - You are able to follow instructions and fill out questionnaires - You have access to a smartphone (for a Fitbit) and a laptop or tablet (for video calls) **You may NOT be eligible if...** - You have a chronic medical condition preventing exercise - You have significant cognitive impairment, severe depression, or an eating disorder - Your cognitive test score is below 21/30 on a standard memory test - You have MRI contraindications (metal implants, pacemaker, etc.) - You are already doing 3+ hours per week of moderate-vigorous exercise AND have completed mindfulness training or score high on the MIND diet questionnaire - You are pregnant, breastfeeding, or have a history of drug/alcohol abuse - You have an active bacterial/viral infection, GI cancer, or inflammatory bowel disease Talk to your doctor to see if this trial is right for you.