Effect of Trendelenburg Position on Patient State Index
Effect of the Trendelenburg Position on Patient State Index and Frontal Cerebral Oxygenation: A Prospective Observational Study
Sakarya University
60 participants
May 1, 2026
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to evaluate whether the Trendelenburg position affects electroencephalography-based depth of anesthesia monitoring and cerebral oxygenation during general anesthesia. The main questions it aims to answer are: * Does the Trendelenburg position cause a change in the Patient State Index (PSI), an Electroensephalography (EEG)-derived indicator of anesthetic depth? * Are changes in PSI associated with changes in frontal cerebral oxygen saturation (rSO₂) and hemodynamic parameters? The study will include adult female patients undergoing elective laparoscopic gynecologic surgery under general anesthesia. Participants will receive standard anesthesia and routine intraoperative monitoring. In addition to standard monitoring, Patient State Index (PSI) and frontal cerebral oxygen saturation (rSO₂) will be recorded using non-invasive sensors. No additional intervention will be performed for research purposes. Physiological parameters including PSI, cerebral oxygen saturation, mean arterial pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide will be recorded at predefined intraoperative time points before and after the Trendelenburg position. The study aims to determine whether position-related physiological changes influence EEG-based anesthesia depth indices and to improve the interpretation of intraoperative brain monitoring.
Eligibility
Inclusion Criteria4
- Female patients aged 18-65 years
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for elective laparoscopic hysterectomy under general anesthesia
- Ability to provide written informed consent
Exclusion Criteria5
- History of neurological disease (e.g., stroke, epilepsy)
- Known cerebrovascular disease, glaucoma, or retinal disease
- Severe cardiac or pulmonary disease
- Contraindication to near-infrared spectroscopy sensor placement
- Obesity (Body Mass Index > 35 kg/m²)
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Locations(1)
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NCT07467200