RecruitingPhase 2NCT07487090

Fasted vs. Fed State Exercise

Fasted vs. Fed State Exercise for Cardiovascular Health and Weight Loss


Sponsor

Arkansas Colleges of Health Education

Enrollment

40 participants

Start Date

Jan 5, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to treat or prevent heart disease / obesity is recommended, not all people respond well. Some see significant weight loss and health improvements while others see little changes. For these reasons, new strategies surrounding the use and design of an exercise program are needed. One such strategy could be performing aerobic exercise before breakfast (fasted exercise). When exercising fasted, food/energy stores are low, and one relies on stored body fat for energy. This may help heart health and weight loss. This has never been tested in a program long enough to see such changes. This study will, for the first time, assess the effects of a 16-week aerobic exercise program performed fasted compared to after eating. Outcomes will include blood fats, blood pressure, fat-burning abilities and weight loss. Starting an exercise program can also make people to eat more. This limits the success of exercise. The study will also evaluate ways fasted exercise could change eating, as it possible that fasted exercise could also cause people to eat more, which would limit weight loss and health improvements.


Eligibility

Min Age: 18 YearsMax Age: 59 Years

Inclusion Criteria3

  • Aged 18-59
  • BMI 25-45
  • Healthy enough to exercise

Exclusion Criteria7

  • Taking medications or supplements that are known to influence energy expenditure,
  • Currently exercising more than once per week
  • Currently dieting for weight loss
  • Currently taking weight loss drugs
  • Have had a previous weight loss surgery
  • Currently diagnosed with Diabetes
  • Currently diagnosed with heart disease (Heart failure, uncontrolled hypertension, uncontrolled hypercholesterolemia, Coronary heart disease)

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Interventions

BEHAVIORAL16 week exercise intervention

Both groups will receive a 16-week supervised aerobic exercise program progressing to 1,600 kcal of EE per wk (4 sessions/week) at moderate intensity (40-50% heart rate reserve, HRR).


Locations(1)

Arkansas Colleges of Health Education Research Institure Health and Wellness Center

Fort Smith, Arkansas, United States

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NCT07487090


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