Menopause Effects on Cortico-reticular Functioning
Female Sex Hormone and Menopause Effects on Cortico-reticular Functioning
University of Jyvaskyla
20 participants
Apr 25, 2026
INTERVENTIONAL
Conditions
Summary
Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.
Eligibility
Inclusion Criteria5
- at least 6 months since their last period but no more than being 5 years post-menopausal
- basal follicular-stimulating hormone concentration > 30 IU/L (confirmed post-recruitment)
- willing to start combined hormonal treatment
- womb and ovaries intact with normal functioning throughout reproductive age
- willing to provide informed consent
Exclusion Criteria7
- classified as excessively obese via BMI assessment (i.e., >35 kg/m2)
- intra-uterine device usage during transition to menopause
- cardiovascular or skeletomuscular disease preventing strenuous physical activity
- smoker
- diagnosed psychiatric illness
- epilepsy
- other diagnosed injuries/illness affecting the neuromuscular system
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Interventions
A 12-week, 4 x per week (2 x strength and 2 x endurance) training program to be performed voluntarily by the participants after tests at month 2.
Locations(1)
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NCT07500922