RecruitingNot ApplicableNCT07532694

Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients

Periodontal Status in Kidney Transplant Patients and the Effectiveness of Adjunctive Diode Laser Therapy

Sponsor

Military Hospital 103

Enrollment

80 participants

Start Date

Dec 9, 2025

Study Type

INTERVENTIONAL

Conditions

Periodontitis Kidney Transplant Recipients

Summary

This randomized controlled trial evaluates the efficacy of diode laser-assisted non-surgical periodontal therapy in kidney transplant recipients with periodontitis. Eighty participants will be allocated to two parallel groups: scaling and root planing (SRP) with adjunctive diode laser therapy or SRP alone. Clinical periodontal parameters, blood biomarkers, radiographic findings, and subgingival microbiome profiles will be assessed at baseline and during follow-up. The study aims to determine whether adjunctive diode laser therapy provides superior clinical and biological improvement compared with SRP alone.

Eligibility

Inclusion Criteria4

Kidney transplant recipients aged 18 years or older.
Diagnosis of periodontitis according to the study case definition.
Medically stable and able to undergo non-surgical periodontal treatment.
Willing and able to provide written informed consent and attend follow-up visits.

Exclusion Criteria5

\- Periodontal treatment or systemic antibiotic use within the predefined exclusion window in the protocol.
Acute oral infection requiring urgent treatment.
Pregnancy or lactation, if excluded by the approved protocol.
Serious systemic condition or clinical instability judged by investigators to preclude study participation.
Inability to comply with study procedures or follow-up schedule.

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Interventions

PROCEDUREScaling and Root Planing

Conventional non-surgical periodontal therapy performed according to the study protocol in both groups.

DEVICEDiode Laser

Adjunctive diode laser application to periodontal pockets after SRP in the experimental arm. Device specifications, wavelength, power settings, mode, fiber size, number of applications, and treatment sessions should match the approved protocol exactly.