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RecruitingNot ApplicableNCT07536568

Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia

Efficacy of Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia: A Double-Blind Randomized Controlled Trial

Sponsor

Cairo University

Enrollment

50 participants

Start Date

Apr 18, 2026

Study Type

INTERVENTIONAL

Conditions

CaffeineRecovery TimeSublingual

Summary

This study aims to evaluate the efficacy of sublingual caffeine in reducing recovery time and incidence of postoperative agitation in elderly patients undergoing general anesthesia.

Eligibility

Min Age: 65 Years

Inclusion Criteria4

  • Age ≥ 65 years.
  • Both sexes.
  • American Society of Anesthesiologists (ASA) physical status II.
  • Scheduled for elective ophthalmology surgery under general anesthesia.

Exclusion Criteria9

  • History of severe cardiac arrhythmias or uncontrolled hypertension.
  • ASA III patients were excluded to reduce the risk of adverse events in elderly patients with severe systemic diseases.
  • Known allergy or hypersensitivity to caffeine.
  • Pre-existing cognitive impairment or dementia (All patients will undergo preoperative cognitive screening using the online Mini-Cog test or Montreal Cognitive Assessment \[MoCA\]).
  • History of seizures or epilepsy.
  • History of alcohol or drug abuse.
  • Chronic use of CNS stimulants or sedatives.
  • Emergency surgeries.
  • Prolonged procedures for more than 3 hours.

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Interventions

DRUGCaffine citrate

Patients will receive sublingual caffeine at the end of surgery.

OTHERPlacebo

Patients will receive sublingual placebo at the end of surgery.

Locations(1)

Cairo University

Cairo, Egypt

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NCT07536568

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