RecruitingPhase 2NCT07575932

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)

Sponsor

Pfizer

Enrollment

872 participants

Start Date

May 11, 2026

Study Type

INTERVENTIONAL

Conditions

Obesity Body Weight Overweight Overweight or Obesity Nutritional and Metabolic Diseases Overnutrition Nutrition Disorders Overweight and/or Obesity

Summary

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called PF-08653944, a drug called PF-08653945, and others for people with body weight, nutrition disorders, and other related conditions. The study is currently recruiting participants at 48 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPF-08653945

Subcutaneous Injection

DRUGPF-08653944

Subcutaneous Injection

DRUGPlacebo

Subcutaneous Injection

Locations(48)

Arizona Clinical Trials-Chandler

Chandler, Arizona, United States

Clinical Research Institute of Arizona

Sun City West, Arizona, United States

Arizona Clinical Trials (ACT) - Tucson

Tucson, Arizona, United States

Ark Clinical Research

Fountain Valley, California, United States

Paragon Rx Clinical

Garden Grove, California, United States

Ark Clinical Research

Long Beach, California, United States

Collaborative Neuroscience Research, LLC

Los Alamitos, California, United States

Paradigm Clinical Research-Modesto

Modesto, California, United States

Paradigm Clinical Research Centers, LLC

San Diego, California, United States

University Clinical Investigators, Incorporated

Tustin, California, United States

Diablo Clinical Research, LLC dba Flourish Research

Walnut Creek, California, United States

AGA Clinical Trials

Hialeah, Florida, United States

Westside Center for Clinical Research

Jacksonville, Florida, United States

New Horizon Research Center

Miami, Florida, United States

Charter Research

Orlando, Florida, United States

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Clinical Research Atlanta

Stockbridge, Georgia, United States

Koch Family Medicine Clinical Research/Elite Research Network

Morton, Illinois, United States

Bioluminux Clinical Research Illinois

Naperville, Illinois, United States

Johnson County Clinical Trials

Lenexa, Kansas, United States

DelRicht Research

Mandeville, Louisiana, United States

DelRicht Research

Prairieville, Louisiana, United States

Patient First Clinical Trials (PFCTRIALS)

Lutherville, Maryland, United States

DelRicht Research

Springfield, Missouri, United States

Mercury Street Medical Group, PLLC

Butte, Montana, United States

Alliance Clinical Research Las Vegas (Excel Clinical Research)

Las Vegas, Nevada, United States

AB Clinical Trials

Las Vegas, Nevada, United States

Bioluminux Clinical Research

Hamilton, New Jersey, United States

DelRicht Research

Charlotte, North Carolina, United States

Monroe Biomedical Research

Monroe, North Carolina, United States

Piedmont Healthcare

Statesville, North Carolina, United States

Tekton Research, LLC.

Edmond, Oklahoma, United States

Preferred Primary Care Physicians

Pittsburgh, Pennsylvania, United States

Preferred Primary Care Physicians

Uniontown, Pennsylvania, United States

TMA Headlands LLC (d/b/a Trial Management Associates)

Myrtle Beach, South Carolina, United States

DelRicht Research

Hendersonville, Tennessee, United States

Cedar Health Research - Euless

Euless, Texas, United States

JCCT-JUNO NW Houston

Houston, Texas, United States

Activian Clinical Research

Kingwood, Texas, United States

3A Research

Plano, Texas, United States

DelRicht Research @ Zomnir Family Medicine

Prosper, Texas, United States

Worldwide Clinical Trials

San Antonio, Texas, United States

Tekton Research, LLC.

San Antonio, Texas, United States

DM Clinical Research

Tomball, Texas, United States

Alpine Medical Group

Salt Lake City, Utah, United States

Wasatch Clinical Research, LLC

Salt Lake City, Utah, United States

Manassas Clinical Research Center

Manassas, Virginia, United States

DelRicht Research

Vienna, Virginia, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07575932

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