EFFECTS OF PROPOLIS AND ROYAL JELLY SUPPLEMENTATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION
Universidade Federal Fluminense
48 participants
Oct 15, 2025
INTERVENTIONAL
Conditions
Summary
The study aims to evaluate the effect of the royal jelly and propolis on inflammation and oxidative stress in participants with systemic arterial hypertension. A longitudinal double-blind randomized clinical trial will be carried out, involving hypertensive participants for two months.
Eligibility
Inclusion Criteria3
- Diagnosis of stage 1 and 2 hypertension
- Regular treatment for more than 6 months
- There have been no changes in medication doses over the last three months.
Exclusion Criteria6
- Autoimmune and infectious diseases, diabetes
- Chronic kidney disease, liver disease, cancer and AIDS
- Pregnant women
- Use of catabolic drugs or antibiotics
- Use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotic
- Habitual intake of royal jelly and propolis
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Interventions
The placebo group will receive 4 capsules per day (containing microcrystalline cellulose and magnesium stearate in colored gelatin capsules capable of masking the appearance of the internal content), at the same time for 2 months.
Participants will receive 4 capsules per day, providing the dosage of 300mg of royal jelly + 500mg propolis for 2 months (8 weeks).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07596966